3DP Printing of Oral Solid Formulations: A Systematic Review

Three-dimensional (3D) printing is a recent technology, which gives the possibility to manufacture personalised dosage forms and it has broad range of applications. One most developed, oral solid four 3DP techniques have been more used for their are FDM, inkjet 3DP, SLA SLS. This systematic review carried out statistically analyze current employed in manufacturing formulations assess trends this new technology. The work organised into steps, (1) screening articles, definition inclusion exclusion criteria classification articles two main groups (included/excluded); (2) quantification characterisation included articles; (3) evaluation validity data extraction process; (4) analysis, discussion, conclusion define technique offers best properties be applied formulations. It observed that with SLS technique, all tests required by BP (drug content, drug dissolution profile, hardness, friability, disintegration time uniformity weight) performed majority except friability test. However, not possible suitable formulations, because selection affected different parameters, such as type formulation, physical-mechanical achieve. Moreover, each its specific advantages disadvantages, FDM biggest challenge degradation drug, due high temperature process or toxicity carcinogenic risk photopolymerising material.